In the games, the Plasma Blaster had an ammunition counter. If the counter fell to zero, the blaster was able to slowly recharge itself back to a maximum of 100 rounds, but the player was forced to collect Plasma Blaster icons to refill ammunition any higher. This would leave the player fairly vulnerable to enemy attacks. There were also Mega Plasma Blaster icons scattered about the levels, allowing the player to shoot a long, powerful blast. In the Special Edition of the game, the Plasma Blaster could also be equipped with Homing Missile ammunition, which would target any nearby enemy without having to aim.
In Earthworm Jim 2, different types of guns were added in addition to the Plasma Blaster.